PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways

Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for the degradation of poly(ADP-ribose). PARG dysfunction sensitizes cells to alkylating agents and induces cell death; however, the details of this effect have not been fully elucidated. Here, we investigated the mechanism by...

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Detalles Bibliográficos
Autores principales: Shirai, H, Poetsch, A R, Gunji, A, Maeda, D, Fujimori, H, Fujihara, H, Yoshida, T, Ogino, H, Masutani, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698538/
https://www.ncbi.nlm.nih.gov/pubmed/23744356
http://dx.doi.org/10.1038/cddis.2013.133

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