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The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. It seems that long-chain polyunsaturated fatty acids (LC-PUFAs) can regulate PPAR γ expression. The purpose of this stu...

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Autores principales: Taraghijou, Parizad, Safaeiyan, Abdolrasoul, Mobasseri, Majid, Ostadrahimi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698653/
https://www.ncbi.nlm.nih.gov/pubmed/23825994
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author Taraghijou, Parizad
Safaeiyan, Abdolrasoul
Mobasseri, Majid
Ostadrahimi, Alireza
author_facet Taraghijou, Parizad
Safaeiyan, Abdolrasoul
Mobasseri, Majid
Ostadrahimi, Alireza
author_sort Taraghijou, Parizad
collection PubMed
description BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. It seems that long-chain polyunsaturated fatty acids (LC-PUFAs) can regulate PPAR γ expression. The purpose of this study was to investigate the effects of n-3LC PUFA supplementation on plasma levels of PPAR γ and thyroid hormones in obesity. MATERIALS AND METHODS: In a randomized double-blind controlled trial, 66 subjects with obesity were assigned to 2 groups. Participants in intervention group consumed omega3 capsules contained 1000 mg n-3 fatty acids (180 mg of eicosapentaenoic acid [EPA] and 120 mg of docosahexaenoic acid [DHA]) and placebo group consumed placebo capsules contained paraffin twice a day for 4 wk. Fasting blood samples and weight measurements were collected at the baseline and at the end of the trial. Plasma PPAR γ and thyroid hormones were measured by ELISA. Data were analyzed using a repeated measure model-two factor for comparing two groups in two times. RESULTS: No significant changes were observed in PPAR γ levels between and within the groups after supplementation (P>0.05). N-3LC PUFA supplementation significantly increased T4 levels after 4 wk (P<0.05) but T3 and TSH did not change significantly. CONCLUSION: Our study showed that n-3LC PUFAs supplementation increased T4 levels. However, no significant changes in T3, TSH and PPAR γ plasma levels were observed in obese adults.
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spelling pubmed-36986532013-07-03 The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity Taraghijou, Parizad Safaeiyan, Abdolrasoul Mobasseri, Majid Ostadrahimi, Alireza J Res Med Sci Original Article BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. It seems that long-chain polyunsaturated fatty acids (LC-PUFAs) can regulate PPAR γ expression. The purpose of this study was to investigate the effects of n-3LC PUFA supplementation on plasma levels of PPAR γ and thyroid hormones in obesity. MATERIALS AND METHODS: In a randomized double-blind controlled trial, 66 subjects with obesity were assigned to 2 groups. Participants in intervention group consumed omega3 capsules contained 1000 mg n-3 fatty acids (180 mg of eicosapentaenoic acid [EPA] and 120 mg of docosahexaenoic acid [DHA]) and placebo group consumed placebo capsules contained paraffin twice a day for 4 wk. Fasting blood samples and weight measurements were collected at the baseline and at the end of the trial. Plasma PPAR γ and thyroid hormones were measured by ELISA. Data were analyzed using a repeated measure model-two factor for comparing two groups in two times. RESULTS: No significant changes were observed in PPAR γ levels between and within the groups after supplementation (P>0.05). N-3LC PUFA supplementation significantly increased T4 levels after 4 wk (P<0.05) but T3 and TSH did not change significantly. CONCLUSION: Our study showed that n-3LC PUFAs supplementation increased T4 levels. However, no significant changes in T3, TSH and PPAR γ plasma levels were observed in obese adults. Medknow Publications & Media Pvt Ltd 2012-10 /pmc/articles/PMC3698653/ /pubmed/23825994 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Taraghijou, Parizad
Safaeiyan, Abdolrasoul
Mobasseri, Majid
Ostadrahimi, Alireza
The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
title The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
title_full The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
title_fullStr The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
title_full_unstemmed The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
title_short The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
title_sort effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698653/
https://www.ncbi.nlm.nih.gov/pubmed/23825994
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