SMAD3 Deficiency Promotes Inflammatory Aortic Aneurysms in Angiotensin II–Infused Mice Via Activation of iNOS

BACKGROUND: Ninety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms‐osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients stil...

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Detalles Bibliográficos
Autores principales: Tan, Chek K., Tan, Eddie H., Luo, Baiwen, Huang, Charlotte L., Loo, Joachim S., Choong, Cleo, Tan, Nguan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698794/
https://www.ncbi.nlm.nih.gov/pubmed/23782924
http://dx.doi.org/10.1161/JAHA.113.000269

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