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Favorable Impact of Growth Hormone Treatment on Cholesterol Levels in Turner Syndrome

Background: Patients with Turner syndrome (TS) are prone to having metabolic abnormalities, such as obesity, dyslipidemia, hypertension, hyperinsulinemia and type 2 diabetes mellitus, resulting in increased risks of developing atherosclerotic diseases. Objective: To determine the effect of growth ho...

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Detalles Bibliográficos
Autores principales: Kohno, Hitoshi, Igarashi, Yutaka, Ozono, Keiichi, Ohyama, Kenji, Ogawa, Masamichi, Osada, Hisao, Onigata, Kazumichi, Kanzaki, Susumu, Seino, Yoshiki, Takahashi, Hiroaki, Tajima, Toshihiro, Tachibana, Katsuhiko, Tanaka, Hiroyuki, Nishi, Yoshikazu, Hasegawa, Tomonobu, Fujieda, Kenji, Fujita, Keinosuke, Horikawa, Reiko, Yokoya, Susumu, Yorifuji, Toru, Tanaka, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698903/
https://www.ncbi.nlm.nih.gov/pubmed/23926408
http://dx.doi.org/10.1297/cpe.21.29
Descripción
Sumario:Background: Patients with Turner syndrome (TS) are prone to having metabolic abnormalities, such as obesity, dyslipidemia, hypertension, hyperinsulinemia and type 2 diabetes mellitus, resulting in increased risks of developing atherosclerotic diseases. Objective: To determine the effect of growth hormone (GH) therapy on serum cholesterol levels in prepubertal girls with TS enrolled in the Turner syndrome Research Collaboration (TRC) in Japan. Patients and methods: Eighty-one girls with TS were enrolled in the TRC, and their total cholesterol (TC) levels before GH therapy were compared with reported levels of healthy school-aged Japanese girls. TC levels after 1, 2 and 3 yr of GH treatment were available for 28 of the 81 patients with TS. GH was administered by daily subcutaneous injections, 6 or 7 times/wk, with a weekly dose of 0.35 mg/kg body weight. Results: Baseline TC levels revealed an age-related increase in TS that was in contrast to healthy girls showing unchanged levels. During GH therapy, TC decreased significantly after 1 yr of GH treatment and remained low thereafter. Conclusions: Girls with untreated TS showed an age-related increase in TC that was a striking contrast to healthy girls, who showed unchanged levels. GH therapy in girls with TS brought about a favorable change in TC that indicates the beneficial impact of GH on atherogenic risk.