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A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells

The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3(+)CD4(+) T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg signature. Computational network inference and experimental testing assessed the co...

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Detalles Bibliográficos
Autores principales:	Fu, Wenxian, Ergun, Ayla, Lu, Ting, Hill, Jonathan A., Haxhinasto, Sokol, Fassett, Marlys S., Gazit, Roi, Adoro, Stanley, Glimcher, Laurie, Chan, Susan, Kastner, Philippe, Rossi, Derrick, Collins, James J., Mathis, Diane, Benoist, Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698954/ https://www.ncbi.nlm.nih.gov/pubmed/22961053 http://dx.doi.org/10.1038/ni.2420

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