The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal dementia—frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP). To date, the C-terminus...

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Detalles Bibliográficos
Autores principales: Zhang, Yong-Jie, Caulfield, Thomas, Xu, Ya-Fei, Gendron, Tania F., Hubbard, Jaime, Stetler, Caroline, Sasaguri, Hiroki, Whitelaw, Ena C., Cai, Shuyi, Lee, Wing Cheung, Petrucelli, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699067/
https://www.ncbi.nlm.nih.gov/pubmed/23575225
http://dx.doi.org/10.1093/hmg/ddt166

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