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Cooperative Binding

Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration....

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Detalles Bibliográficos
Autores principales: Stefan, Melanie I., Le Novère, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699289/
https://www.ncbi.nlm.nih.gov/pubmed/23843752
http://dx.doi.org/10.1371/journal.pcbi.1003106
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author Stefan, Melanie I.
Le Novère, Nicolas
author_facet Stefan, Melanie I.
Le Novère, Nicolas
author_sort Stefan, Melanie I.
collection PubMed
description Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes.
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spelling pubmed-36992892013-07-10 Cooperative Binding Stefan, Melanie I. Le Novère, Nicolas PLoS Comput Biol Topic Page Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes. Public Library of Science 2013-06-27 /pmc/articles/PMC3699289/ /pubmed/23843752 http://dx.doi.org/10.1371/journal.pcbi.1003106 Text en © 2013 Stefan, Le Novère http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Topic Page
Stefan, Melanie I.
Le Novère, Nicolas
Cooperative Binding
title Cooperative Binding
title_full Cooperative Binding
title_fullStr Cooperative Binding
title_full_unstemmed Cooperative Binding
title_short Cooperative Binding
title_sort cooperative binding
topic Topic Page
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699289/
https://www.ncbi.nlm.nih.gov/pubmed/23843752
http://dx.doi.org/10.1371/journal.pcbi.1003106
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