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Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma
The objective of the study was to evaluate the long term results of the sentinel node (SN) biopsy technique in the management of the clinically negative (N0) neck in patients with early oral squamous cell carcinoma (T1–T2). Patients with positive SN underwent neck dissection. A sentinel lymph node (...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699346/ https://www.ncbi.nlm.nih.gov/pubmed/23836993 http://dx.doi.org/10.2147/OTT.S43446 |
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author | Dequanter, Didier Shahla, Mohammad Paulus, Pascal Lothaire, Philippe |
author_facet | Dequanter, Didier Shahla, Mohammad Paulus, Pascal Lothaire, Philippe |
author_sort | Dequanter, Didier |
collection | PubMed |
description | The objective of the study was to evaluate the long term results of the sentinel node (SN) biopsy technique in the management of the clinically negative (N0) neck in patients with early oral squamous cell carcinoma (T1–T2). Patients with positive SN underwent neck dissection. A sentinel lymph node (SLN) biopsy was performed on 31 consecutive patients. Six of the 31 patients were upstaged by the results of the SLN biopsy. The SLN biopsy allowed the identification of node metastasis in 100% of the cases with a sensitivity of 100%, specificity of 100%, and negative predictive value of 100%. There was a mean follow-up of 59 months. The neck control rate was 100% in the SLN negative group and two SLN positive patients developed subsequent neck disease (neck control rate of 88%). One SLN patient presented at the follow-up with a second primary tumor, 18 months later treated successfully by chemoradiotherapy. The overall survival rate was 100% in both groups. The promising reported short-term results have been sustained by long term follow-up. Patients with negative SLN achieved an excellent neck control rate. The neck control rate in SN negative patients was superior to that in SLN positive patients, but not statistically different. |
format | Online Article Text |
id | pubmed-3699346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36993462013-07-08 Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma Dequanter, Didier Shahla, Mohammad Paulus, Pascal Lothaire, Philippe Onco Targets Ther Case Series The objective of the study was to evaluate the long term results of the sentinel node (SN) biopsy technique in the management of the clinically negative (N0) neck in patients with early oral squamous cell carcinoma (T1–T2). Patients with positive SN underwent neck dissection. A sentinel lymph node (SLN) biopsy was performed on 31 consecutive patients. Six of the 31 patients were upstaged by the results of the SLN biopsy. The SLN biopsy allowed the identification of node metastasis in 100% of the cases with a sensitivity of 100%, specificity of 100%, and negative predictive value of 100%. There was a mean follow-up of 59 months. The neck control rate was 100% in the SLN negative group and two SLN positive patients developed subsequent neck disease (neck control rate of 88%). One SLN patient presented at the follow-up with a second primary tumor, 18 months later treated successfully by chemoradiotherapy. The overall survival rate was 100% in both groups. The promising reported short-term results have been sustained by long term follow-up. Patients with negative SLN achieved an excellent neck control rate. The neck control rate in SN negative patients was superior to that in SLN positive patients, but not statistically different. Dove Medical Press 2013-06-25 /pmc/articles/PMC3699346/ /pubmed/23836993 http://dx.doi.org/10.2147/OTT.S43446 Text en © 2013 Dequanter et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Case Series Dequanter, Didier Shahla, Mohammad Paulus, Pascal Lothaire, Philippe Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
title | Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
title_full | Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
title_fullStr | Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
title_full_unstemmed | Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
title_short | Long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
title_sort | long term results of sentinel lymph node biopsy in early oral squamous cell carcinoma |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699346/ https://www.ncbi.nlm.nih.gov/pubmed/23836993 http://dx.doi.org/10.2147/OTT.S43446 |
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