Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

BACKGROUND: Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT) and invasion. However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog (Hh) signaling in hypoxia induced pancreatic cancer EMT and invasion. METHODS:...

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Detalles Bibliográficos
Autores principales: Lei, Jianjun, Ma, Jiguang, Ma, Qingyong, Li, Xuqi, Liu, Han, Xu, Qinhong, Duan, Wanxing, Sun, Qing, Xu, Jun, Wu, Zheng, Wu, Erxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699387/
https://www.ncbi.nlm.nih.gov/pubmed/23786654
http://dx.doi.org/10.1186/1476-4598-12-66

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