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Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis

BACKGROUND: Circulating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagnosis of gastric cancer. METHODS: A systematic review and meta-analysis was perf...

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Autores principales: Tang, Lanhua, Zhao, Shushan, Liu, Wei, Parchim, Nicholas F, Huang, Jin, Tang, Youhong, Gan, Pingping, Zhong, Meizuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699416/
https://www.ncbi.nlm.nih.gov/pubmed/23806209
http://dx.doi.org/10.1186/1471-2407-13-314
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author Tang, Lanhua
Zhao, Shushan
Liu, Wei
Parchim, Nicholas F
Huang, Jin
Tang, Youhong
Gan, Pingping
Zhong, Meizuo
author_facet Tang, Lanhua
Zhao, Shushan
Liu, Wei
Parchim, Nicholas F
Huang, Jin
Tang, Youhong
Gan, Pingping
Zhong, Meizuo
author_sort Tang, Lanhua
collection PubMed
description BACKGROUND: Circulating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagnosis of gastric cancer. METHODS: A systematic review and meta-analysis was performed to evaluate the overall accuracy of CTCs detection for diagnosing gastric cancer. PubMed, Embase and the Wanfang database were searched in all languages published up to Oct 2012. The pooled sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR, respectively), diagnostic odds ratio (DOR) and summary receiver operating characteristic (sROC) curve were calculated to evaluate the overall test performance. RESULTS: Twenty studies were included in this systematic review and meta-analysis. The diagnostic value of CTCs detection for the gastric cancer was calculated to evaluate the overall test performance. The summary estimates of The pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio were 0.42 (95% confidence interval (CI), 0.21-0.67), 0.99 (95% CI, 0.96-1.00), 58.2 (95% CI, 9.8-345.9), 0.58 (95% CI, 0.38-0.89), and 100 (95% CI, 15–663), respectively. The summary receiver operating characteristic curve was 0.97 (95% CI, 0.95–0.98). Deek’s funnel plot asymmetry test found no evidence of study publication bias in the current study (P = 0.49). CONCLUSION: This systematic review suggests that CTCs detection alone cannot be recommended as a screening test for gastric cancer. However, it might be used as a noninvasive method for the confirmation of the gastric cancer diagnosis.
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spelling pubmed-36994162013-07-03 Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis Tang, Lanhua Zhao, Shushan Liu, Wei Parchim, Nicholas F Huang, Jin Tang, Youhong Gan, Pingping Zhong, Meizuo BMC Cancer Research Article BACKGROUND: Circulating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagnosis of gastric cancer. METHODS: A systematic review and meta-analysis was performed to evaluate the overall accuracy of CTCs detection for diagnosing gastric cancer. PubMed, Embase and the Wanfang database were searched in all languages published up to Oct 2012. The pooled sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR, respectively), diagnostic odds ratio (DOR) and summary receiver operating characteristic (sROC) curve were calculated to evaluate the overall test performance. RESULTS: Twenty studies were included in this systematic review and meta-analysis. The diagnostic value of CTCs detection for the gastric cancer was calculated to evaluate the overall test performance. The summary estimates of The pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio were 0.42 (95% confidence interval (CI), 0.21-0.67), 0.99 (95% CI, 0.96-1.00), 58.2 (95% CI, 9.8-345.9), 0.58 (95% CI, 0.38-0.89), and 100 (95% CI, 15–663), respectively. The summary receiver operating characteristic curve was 0.97 (95% CI, 0.95–0.98). Deek’s funnel plot asymmetry test found no evidence of study publication bias in the current study (P = 0.49). CONCLUSION: This systematic review suggests that CTCs detection alone cannot be recommended as a screening test for gastric cancer. However, it might be used as a noninvasive method for the confirmation of the gastric cancer diagnosis. BioMed Central 2013-06-27 /pmc/articles/PMC3699416/ /pubmed/23806209 http://dx.doi.org/10.1186/1471-2407-13-314 Text en Copyright © 2013 Tang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tang, Lanhua
Zhao, Shushan
Liu, Wei
Parchim, Nicholas F
Huang, Jin
Tang, Youhong
Gan, Pingping
Zhong, Meizuo
Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
title Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
title_full Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
title_fullStr Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
title_full_unstemmed Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
title_short Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
title_sort diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699416/
https://www.ncbi.nlm.nih.gov/pubmed/23806209
http://dx.doi.org/10.1186/1471-2407-13-314
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