IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that cellular immunity to AAV represents a major challenge facing the clinical use of systemic administration of these vectors. Interestingly, no prec...

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Detalles Bibliográficos
Autores principales: Gil-Fariña, Irene, Di Scala, Marianna, Vanrell, Lucia, Olagüe, Cristina, Vales, Africa, High, Katherine A., Prieto, Jesus, Mingozzi, Federico, Gonzalez-Aseguinolaza, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699534/
https://www.ncbi.nlm.nih.gov/pubmed/23844082
http://dx.doi.org/10.1371/journal.pone.0067748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699534/
https://www.ncbi.nlm.nih.gov/pubmed/23844082
http://dx.doi.org/10.1371/journal.pone.0067748

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