The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials

BACKGROUND: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 random...

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Detalles Bibliográficos
Autores principales: Leaper, David, Münter, Christian, Meaume, Sylvie, Scalise, Alessandro, Mompó, Nacho Blanes, Jakobsen, Birte Petersen, Gottrup, Finn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699549/
https://www.ncbi.nlm.nih.gov/pubmed/23843984
http://dx.doi.org/10.1371/journal.pone.0067083
Descripción
Sumario:BACKGROUND: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs). AIM: To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing. PATIENTS AND METHODS: 685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis. RESULTS: Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002). CONCLUSION: The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.

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