The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials

BACKGROUND: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 random...

Descripción completa

Detalles Bibliográficos
Autores principales: Leaper, David, Münter, Christian, Meaume, Sylvie, Scalise, Alessandro, Mompó, Nacho Blanes, Jakobsen, Birte Petersen, Gottrup, Finn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699549/
https://www.ncbi.nlm.nih.gov/pubmed/23843984
http://dx.doi.org/10.1371/journal.pone.0067083
_version_ 1782275408985587712
author Leaper, David
Münter, Christian
Meaume, Sylvie
Scalise, Alessandro
Mompó, Nacho Blanes
Jakobsen, Birte Petersen
Gottrup, Finn
author_facet Leaper, David
Münter, Christian
Meaume, Sylvie
Scalise, Alessandro
Mompó, Nacho Blanes
Jakobsen, Birte Petersen
Gottrup, Finn
author_sort Leaper, David
collection PubMed
description BACKGROUND: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs). AIM: To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing. PATIENTS AND METHODS: 685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis. RESULTS: Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002). CONCLUSION: The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.
format Online
Article
Text
id pubmed-3699549
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-36995492013-07-10 The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials Leaper, David Münter, Christian Meaume, Sylvie Scalise, Alessandro Mompó, Nacho Blanes Jakobsen, Birte Petersen Gottrup, Finn PLoS One Research Article BACKGROUND: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs). AIM: To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing. PATIENTS AND METHODS: 685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis. RESULTS: Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002). CONCLUSION: The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers. Public Library of Science 2013-07-02 /pmc/articles/PMC3699549/ /pubmed/23843984 http://dx.doi.org/10.1371/journal.pone.0067083 Text en © 2013 Leaper et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Leaper, David
Münter, Christian
Meaume, Sylvie
Scalise, Alessandro
Mompó, Nacho Blanes
Jakobsen, Birte Petersen
Gottrup, Finn
The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials
title The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials
title_full The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials
title_fullStr The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials
title_full_unstemmed The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials
title_short The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials
title_sort use of biatain ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699549/
https://www.ncbi.nlm.nih.gov/pubmed/23843984
http://dx.doi.org/10.1371/journal.pone.0067083
work_keys_str_mv AT leaperdavid theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT munterchristian theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT meaumesylvie theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT scalisealessandro theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT momponachoblanes theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT jakobsenbirtepetersen theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT gottrupfinn theuseofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT leaperdavid useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT munterchristian useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT meaumesylvie useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT scalisealessandro useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT momponachoblanes useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT jakobsenbirtepetersen useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials
AT gottrupfinn useofbiatainaginhardtohealvenouslegulcersmetaanalysisofrandomisedcontrolledtrials

Ejemplares similares