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Analysis of Conformational Determinants Underlying HSP90-Kinase Interaction

The role of HSP90 in stabilization of oncogenic tyrosine kinases made it an attractive therapeutic target for treating cancer but the molecular basis underlying the interaction between the HSP90 chaperone and client kinases is not elucidated yet. Using kinase inhibitors we show that the inactive con...

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Detalles Bibliográficos
Autores principales:	Kancha, Rama Krishna, Bartosch, Natalie, Duyster, Justus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699556/ https://www.ncbi.nlm.nih.gov/pubmed/23844194 http://dx.doi.org/10.1371/journal.pone.0068394

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