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Analysis of Conformational Determinants Underlying HSP90-Kinase Interaction
The role of HSP90 in stabilization of oncogenic tyrosine kinases made it an attractive therapeutic target for treating cancer but the molecular basis underlying the interaction between the HSP90 chaperone and client kinases is not elucidated yet. Using kinase inhibitors we show that the inactive con...
Autores principales: | Kancha, Rama Krishna, Bartosch, Natalie, Duyster, Justus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699556/ https://www.ncbi.nlm.nih.gov/pubmed/23844194 http://dx.doi.org/10.1371/journal.pone.0068394 |
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