Cargando…
Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients
BACKGROUND: Platelet-to-Lymphocyte Ratio (PLR) is an easily applicable blood test. An elevated PLR has been associated with poor prognosis in patients with different oncologic disorder. As platelets play a key role in atherosclerosis and atherothrombosis, we investigated PLR and its association with...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699634/ https://www.ncbi.nlm.nih.gov/pubmed/23844064 http://dx.doi.org/10.1371/journal.pone.0067688 |
_version_ | 1782275428305600512 |
---|---|
author | Gary, Thomas Pichler, Martin Belaj, Klara Hafner, Franz Gerger, Armin Froehlich, Harald Eller, Philipp Rief, Peter Hackl, Gerald Pilger, Ernst Brodmann, Marianne |
author_facet | Gary, Thomas Pichler, Martin Belaj, Klara Hafner, Franz Gerger, Armin Froehlich, Harald Eller, Philipp Rief, Peter Hackl, Gerald Pilger, Ernst Brodmann, Marianne |
author_sort | Gary, Thomas |
collection | PubMed |
description | BACKGROUND: Platelet-to-Lymphocyte Ratio (PLR) is an easily applicable blood test. An elevated PLR has been associated with poor prognosis in patients with different oncologic disorder. As platelets play a key role in atherosclerosis and atherothrombosis, we investigated PLR and its association with critical limb ischemia (CLI) and other vascular endpoints in peripheral arterial occlusive disease (PAOD) patients. METHODS AND FINDINGS: We evaluated 2121 PAOD patients treated at our institution from 2005 to 2010. PLR was calculated and the cohort was categorized into tertiles according to the PLR. An optimal cut-off value for the continuous PLR was calculated by applying a receiver operating curve analysis to discriminate between CLI and non-CLI. In our cohort occurrence of CLI significantly increased with an increase in PLR. As an optimal cut-off value, a PLR of 150 was identified. Two groups were categorized, one containing 1228 patients (PLR≤150) and a second group with 893 patients (PLR>150). CLI was more frequent in PLR>150 patients (410(45.9%)) compared to PLR≤150 patients (270(22.0%)) (p<0.001), as was prior myocardial infarction (51(5.7%) vs. 42(3.5%), p = 0.02). Regarding inflammatory parameters, C-reactive protein (median 7.0 mg/l (3.0–24.25) vs. median 5.0 mg/l (2.0–10.0)) and fibrinogen (median 457 mg/dl (359.0–583.0) vs. 372 mg/dl (317.25–455.75)) also significantly differed in the two patient groups (both p<0.001). Finally, a PLR>150 was associated with an OR of 1.9 (95%CI 1.7–2.1) for CLI even after adjustment for other well-established vascular risk factors. CONCLUSIONS: An increased PLR is significantly associated with patients at high risk for CLI and other cardiovascular endpoints. The PLR is a broadly available and cheap marker, which could be used to highlight patients at high risk for vascular endpoints. |
format | Online Article Text |
id | pubmed-3699634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36996342013-07-10 Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients Gary, Thomas Pichler, Martin Belaj, Klara Hafner, Franz Gerger, Armin Froehlich, Harald Eller, Philipp Rief, Peter Hackl, Gerald Pilger, Ernst Brodmann, Marianne PLoS One Research Article BACKGROUND: Platelet-to-Lymphocyte Ratio (PLR) is an easily applicable blood test. An elevated PLR has been associated with poor prognosis in patients with different oncologic disorder. As platelets play a key role in atherosclerosis and atherothrombosis, we investigated PLR and its association with critical limb ischemia (CLI) and other vascular endpoints in peripheral arterial occlusive disease (PAOD) patients. METHODS AND FINDINGS: We evaluated 2121 PAOD patients treated at our institution from 2005 to 2010. PLR was calculated and the cohort was categorized into tertiles according to the PLR. An optimal cut-off value for the continuous PLR was calculated by applying a receiver operating curve analysis to discriminate between CLI and non-CLI. In our cohort occurrence of CLI significantly increased with an increase in PLR. As an optimal cut-off value, a PLR of 150 was identified. Two groups were categorized, one containing 1228 patients (PLR≤150) and a second group with 893 patients (PLR>150). CLI was more frequent in PLR>150 patients (410(45.9%)) compared to PLR≤150 patients (270(22.0%)) (p<0.001), as was prior myocardial infarction (51(5.7%) vs. 42(3.5%), p = 0.02). Regarding inflammatory parameters, C-reactive protein (median 7.0 mg/l (3.0–24.25) vs. median 5.0 mg/l (2.0–10.0)) and fibrinogen (median 457 mg/dl (359.0–583.0) vs. 372 mg/dl (317.25–455.75)) also significantly differed in the two patient groups (both p<0.001). Finally, a PLR>150 was associated with an OR of 1.9 (95%CI 1.7–2.1) for CLI even after adjustment for other well-established vascular risk factors. CONCLUSIONS: An increased PLR is significantly associated with patients at high risk for CLI and other cardiovascular endpoints. The PLR is a broadly available and cheap marker, which could be used to highlight patients at high risk for vascular endpoints. Public Library of Science 2013-07-02 /pmc/articles/PMC3699634/ /pubmed/23844064 http://dx.doi.org/10.1371/journal.pone.0067688 Text en © 2013 Gary et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Gary, Thomas Pichler, Martin Belaj, Klara Hafner, Franz Gerger, Armin Froehlich, Harald Eller, Philipp Rief, Peter Hackl, Gerald Pilger, Ernst Brodmann, Marianne Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients |
title | Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients |
title_full | Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients |
title_fullStr | Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients |
title_full_unstemmed | Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients |
title_short | Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients |
title_sort | platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699634/ https://www.ncbi.nlm.nih.gov/pubmed/23844064 http://dx.doi.org/10.1371/journal.pone.0067688 |
work_keys_str_mv | AT garythomas platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT pichlermartin platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT belajklara platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT hafnerfranz platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT gergerarmin platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT froehlichharald platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT ellerphilipp platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT riefpeter platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT hacklgerald platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT pilgerernst platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients AT brodmannmarianne platelettolymphocyteratioanovelmarkerforcriticallimbischemiainperipheralarterialocclusivediseasepatients |