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Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients

The objective of the study was to evaluate the oncological and functional results of transoral laser microsurgery (TLM) in patients with supraglottic laryngeal squamous cell carcinoma. Between June 1980 and December 2006, 277 patients with squamous cell supraglottic carcinoma of all stages were trea...

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Autores principales: Canis, Martin, Martin, Alexios, Ihler, Friedrich, Wolff, Hendrik A., Kron, Martina, Matthias, Christoph, Steiner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699705/
https://www.ncbi.nlm.nih.gov/pubmed/23306348
http://dx.doi.org/10.1007/s00405-012-2327-6
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author Canis, Martin
Martin, Alexios
Ihler, Friedrich
Wolff, Hendrik A.
Kron, Martina
Matthias, Christoph
Steiner, Wolfgang
author_facet Canis, Martin
Martin, Alexios
Ihler, Friedrich
Wolff, Hendrik A.
Kron, Martina
Matthias, Christoph
Steiner, Wolfgang
author_sort Canis, Martin
collection PubMed
description The objective of the study was to evaluate the oncological and functional results of transoral laser microsurgery (TLM) in patients with supraglottic laryngeal squamous cell carcinoma. Between June 1980 and December 2006, 277 patients with squamous cell supraglottic carcinoma of all stages were treated by primary carbon dioxide laser microsurgery. All treatments were performed with curative intention. The goal was the complete tumor removal with preservation of functionally important structures of the larynx. The administered treatment was exclusively TLM with or without selective or modified radical neck dissection in 215 cases (78 %); TLM with postoperative radiotherapy was performed in 62 cases (22 %). Data were analyzed using the Kaplan–Meier method. The median follow-up was 65 months. We achieved a 5-year local control rate of 85 % for pT1/pT2, 82 % for pT3, and 76 % for pT4. The 5-year overall, recurrence-free and disease-specific survival rates for stages I and II were 76, 81, and 92 %, for stages III and IVa 59, 65, and 81 %, respectively. With respect to local control and survival, these results are comparable with the results achieved by conventional partial and total resection of the larynx, while being superior to primary (chemo)radiotherapy. Transoral laser microsurgery results in a low morbidity, rapid recovery, and superior function compared with standard therapy.
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spelling pubmed-36997052013-07-09 Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients Canis, Martin Martin, Alexios Ihler, Friedrich Wolff, Hendrik A. Kron, Martina Matthias, Christoph Steiner, Wolfgang Eur Arch Otorhinolaryngol Head and Neck The objective of the study was to evaluate the oncological and functional results of transoral laser microsurgery (TLM) in patients with supraglottic laryngeal squamous cell carcinoma. Between June 1980 and December 2006, 277 patients with squamous cell supraglottic carcinoma of all stages were treated by primary carbon dioxide laser microsurgery. All treatments were performed with curative intention. The goal was the complete tumor removal with preservation of functionally important structures of the larynx. The administered treatment was exclusively TLM with or without selective or modified radical neck dissection in 215 cases (78 %); TLM with postoperative radiotherapy was performed in 62 cases (22 %). Data were analyzed using the Kaplan–Meier method. The median follow-up was 65 months. We achieved a 5-year local control rate of 85 % for pT1/pT2, 82 % for pT3, and 76 % for pT4. The 5-year overall, recurrence-free and disease-specific survival rates for stages I and II were 76, 81, and 92 %, for stages III and IVa 59, 65, and 81 %, respectively. With respect to local control and survival, these results are comparable with the results achieved by conventional partial and total resection of the larynx, while being superior to primary (chemo)radiotherapy. Transoral laser microsurgery results in a low morbidity, rapid recovery, and superior function compared with standard therapy. Springer Berlin Heidelberg 2013-01-10 2013 /pmc/articles/PMC3699705/ /pubmed/23306348 http://dx.doi.org/10.1007/s00405-012-2327-6 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Head and Neck
Canis, Martin
Martin, Alexios
Ihler, Friedrich
Wolff, Hendrik A.
Kron, Martina
Matthias, Christoph
Steiner, Wolfgang
Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
title Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
title_full Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
title_fullStr Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
title_full_unstemmed Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
title_short Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
title_sort results of transoral laser microsurgery for supraglottic carcinoma in 277 patients
topic Head and Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699705/
https://www.ncbi.nlm.nih.gov/pubmed/23306348
http://dx.doi.org/10.1007/s00405-012-2327-6
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