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Hollow Microporous Organic Capsules
Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699813/ https://www.ncbi.nlm.nih.gov/pubmed/23820511 http://dx.doi.org/10.1038/srep02128 |
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author | Li, Buyi Yang, Xinjia Xia, Lingling Majeed, Muhammad Irfan Tan, Bien |
author_facet | Li, Buyi Yang, Xinjia Xia, Lingling Majeed, Muhammad Irfan Tan, Bien |
author_sort | Li, Buyi |
collection | PubMed |
description | Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying the necessary path for the design of controlled uptake/release systems. Herein, the synthesis of HMOCs with high surface area through facile emulsion polymerization and hypercrosslinking reactions, is described. Due to their tailored porous structure, these capsules possessed high drug loading efficiency, zero-order drug release kinetics and are also demonstrated to be used as nanoscale reactors for the prepareation of nanoparticles (NPs) without any external stabilizer. Moreover, owing to their intrinsic biocompatibility and fluorescence, these capsules exhibit promising prospect for biomedical applications. |
format | Online Article Text |
id | pubmed-3699813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36998132013-07-03 Hollow Microporous Organic Capsules Li, Buyi Yang, Xinjia Xia, Lingling Majeed, Muhammad Irfan Tan, Bien Sci Rep Article Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying the necessary path for the design of controlled uptake/release systems. Herein, the synthesis of HMOCs with high surface area through facile emulsion polymerization and hypercrosslinking reactions, is described. Due to their tailored porous structure, these capsules possessed high drug loading efficiency, zero-order drug release kinetics and are also demonstrated to be used as nanoscale reactors for the prepareation of nanoparticles (NPs) without any external stabilizer. Moreover, owing to their intrinsic biocompatibility and fluorescence, these capsules exhibit promising prospect for biomedical applications. Nature Publishing Group 2013-07-03 /pmc/articles/PMC3699813/ /pubmed/23820511 http://dx.doi.org/10.1038/srep02128 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Li, Buyi Yang, Xinjia Xia, Lingling Majeed, Muhammad Irfan Tan, Bien Hollow Microporous Organic Capsules |
title | Hollow Microporous Organic Capsules |
title_full | Hollow Microporous Organic Capsules |
title_fullStr | Hollow Microporous Organic Capsules |
title_full_unstemmed | Hollow Microporous Organic Capsules |
title_short | Hollow Microporous Organic Capsules |
title_sort | hollow microporous organic capsules |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699813/ https://www.ncbi.nlm.nih.gov/pubmed/23820511 http://dx.doi.org/10.1038/srep02128 |
work_keys_str_mv | AT libuyi hollowmicroporousorganiccapsules AT yangxinjia hollowmicroporousorganiccapsules AT xialingling hollowmicroporousorganiccapsules AT majeedmuhammadirfan hollowmicroporousorganiccapsules AT tanbien hollowmicroporousorganiccapsules |