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Hollow Microporous Organic Capsules

Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying th...

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Detalles Bibliográficos
Autores principales: Li, Buyi, Yang, Xinjia, Xia, Lingling, Majeed, Muhammad Irfan, Tan, Bien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699813/
https://www.ncbi.nlm.nih.gov/pubmed/23820511
http://dx.doi.org/10.1038/srep02128
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author Li, Buyi
Yang, Xinjia
Xia, Lingling
Majeed, Muhammad Irfan
Tan, Bien
author_facet Li, Buyi
Yang, Xinjia
Xia, Lingling
Majeed, Muhammad Irfan
Tan, Bien
author_sort Li, Buyi
collection PubMed
description Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying the necessary path for the design of controlled uptake/release systems. Herein, the synthesis of HMOCs with high surface area through facile emulsion polymerization and hypercrosslinking reactions, is described. Due to their tailored porous structure, these capsules possessed high drug loading efficiency, zero-order drug release kinetics and are also demonstrated to be used as nanoscale reactors for the prepareation of nanoparticles (NPs) without any external stabilizer. Moreover, owing to their intrinsic biocompatibility and fluorescence, these capsules exhibit promising prospect for biomedical applications.
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spelling pubmed-36998132013-07-03 Hollow Microporous Organic Capsules Li, Buyi Yang, Xinjia Xia, Lingling Majeed, Muhammad Irfan Tan, Bien Sci Rep Article Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying the necessary path for the design of controlled uptake/release systems. Herein, the synthesis of HMOCs with high surface area through facile emulsion polymerization and hypercrosslinking reactions, is described. Due to their tailored porous structure, these capsules possessed high drug loading efficiency, zero-order drug release kinetics and are also demonstrated to be used as nanoscale reactors for the prepareation of nanoparticles (NPs) without any external stabilizer. Moreover, owing to their intrinsic biocompatibility and fluorescence, these capsules exhibit promising prospect for biomedical applications. Nature Publishing Group 2013-07-03 /pmc/articles/PMC3699813/ /pubmed/23820511 http://dx.doi.org/10.1038/srep02128 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Li, Buyi
Yang, Xinjia
Xia, Lingling
Majeed, Muhammad Irfan
Tan, Bien
Hollow Microporous Organic Capsules
title Hollow Microporous Organic Capsules
title_full Hollow Microporous Organic Capsules
title_fullStr Hollow Microporous Organic Capsules
title_full_unstemmed Hollow Microporous Organic Capsules
title_short Hollow Microporous Organic Capsules
title_sort hollow microporous organic capsules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699813/
https://www.ncbi.nlm.nih.gov/pubmed/23820511
http://dx.doi.org/10.1038/srep02128
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