Cargando…

Synthesis and Anticancer Activity of 2-(Alkyl-, Alkaryl-, Aryl-, Hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines

The combinatorial library of novel potential anticancer agents, namely, 2-(alkyl-, alkaryl-, aryl-, hetaryl-)[1,2,4]triazolo[1,5-c]quinazolines, was synthesized by the heterocyclization of the alkyl-, alkaryl-, aryl-, hetarylcarboxylic acid (3H-quinazoline-4-ylidene)hydrazides by oxidative heterocyc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovalenko, Sergiy I., Antypenko, Lyudmyla M., Bilyi, Andriy K., Kholodnyak, Sergiy V., Karpenko, Olexandr V., Antypenko, Olexii M., Mykhaylova, Natalya S., Los, Tetyana I., Kolomoets, Olexandra S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Österreichische Apotheker-Verlagsgesellschaft 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700071/ https://www.ncbi.nlm.nih.gov/pubmed/23833709 http://dx.doi.org/10.3797/scipharm.1211-08

Ejemplares similares

Synthesis of New 6-{[ω-(Dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and Evaluation of their Anticancer and Antimicrobial Activities
por: Berest, Galina G., et al.
Publicado: (2012)

Design and Evaluation of Novel Antimicrobial and Anticancer Agents Among Tetrazolo[1,5-c]quinazoline-5-thione S-Derivatives
por: Antypenko, Lyudmyla M., et al.
Publicado: (2013)

Search for Compounds with Hypoglycemic Activity in the Series of 1-[2-(1H-Tetrazol-5-yl)-R(1)-phenyl]-3-R(2)-phenyl(ethyl)ureas and R(1)-Tetrazolo[1,5-c]quinazolin-5(6H)-ones
por: Antypenko, Oleksii M., et al.
Publicado: (2016)

Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity
por: Kovalenko, Sergey I., et al.
Publicado: (2012)

Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase
por: Antypenko, Lyudmyla, et al.
Publicado: (2023)

2-[(3-Aminoalkyl-(alkaryl-,aryl-))-(1)H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity
por: MARTYNENKO, Yulya, et al.
Publicado: (2020)

Directed Search of Anti-inflammatory Agents Among (3H-Quinazoline-4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products
por: Martynenko, Yulya, et al.
Publicado: (2020)

Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives
por: Nosulenko, Inna S., et al.
Publicado: (2014)

A Novel Series of [1,2,4]Triazolo[4,3-a]Pyridine Sulfonamides as Potential Antimalarial Agents: In Silico Studies, Synthesis and In Vitro Evaluation
por: Karpina, Veronika R., et al.
Publicado: (2020)

Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
por: Al-Salahi, Rashad A.
Publicado: (2010)

Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
por: Voskoboynik, Oleksii Yu., et al.
Publicado: (2017)

Synthesis, structure, and biological activity of 4-hetaryl-2-pyrrolidones containing a pyrazole ring
por: Gorodnicheva, Natal’ya V., et al.
Publicado: (2022)

Synthesis and bioactivity of several new hetaryl sulfonamides
por: Taslimi, Parham, et al.
Publicado: (2017)

2-Hetaryl-1,3-tropolones based on five-membered nitrogen heterocycles: synthesis, structure and properties
por: Sayapin, Yury A, et al.
Publicado: (2015)

Hetero-Diels–Alder reactions of hetaryl and aryl thioketones with acetylenic dienophiles
por: Mlostoń, Grzegorz, et al.
Publicado: (2015)

5-Chloro-2-methylsulfonyl-1,2,4-triazolo[1,5-a]quinazoline
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2,6-Dicyano-4-pyrone as a Novel and Multifarious Building Block for the Synthesis of 2,6-Bis(hetaryl)-4-pyrones and 2,6-Bis(hetaryl)-4-pyridinols
por: Obydennov, Dmitrii L., et al.
Publicado: (2020)

Possible therapeutic targets and promising drugs based on unsymmetrical hetaryl-substituted porphyrins to combat SARS-CoV-2
por: Gubarev, Yury A., et al.
Publicado: (2021)

(1R,3S)-3-(1H-Benzo[d]imidazol-2-yl)-1,2,2-trimethylcyclopentane-1-carboxylic acid as a new anti-diabetic active pharmaceutical ingredient
por: Kovalenko, Sergiy M., et al.
Publicado: (2020)

3-Aryl-5-aminobiphenyl Substituted [1,2,4]triazolo[4,3-c]quinazolines: Synthesis and Photophysical Properties
por: Kopotilova, Alexandra E., et al.
Publicado: (2023)

Angular Regioselective Synthesis of Varied Functionalized Hexahydro-1,2,4-triazolo[4,3-a]quinazolin-9-ones and Their Antiproliferative Action †
por: Said, Awad I., et al.
Publicado: (2023)

Synthesis of Hetaryl-Substituted Asymmetric Porphyrins and Their Affinity to SARS-CoV-2 Helicase
por: Syrbu, S. A., et al.
Publicado: (2021)

2-Benzyloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Methylsulfanyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Methylsulfonyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Phenoxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Methylsulfanyl-1,2,4-triazolo[1,5-a]quinazoline-5(4H)-thione
por: Al-Salahi, Rashad, et al.
Publicado: (2013)

Solution-phase Synthesis of a Combinatorial Library of 3-[4-(Coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid Amides
por: Zhuravel, Irina O., et al.
Publicado: (2005)

Usage of Quantum Chemical Methods to Understand the Formation of Concomitant Polymorphs of Acetyl 2-(N-(2-Fluorophenyl)imino)coumarin-3-carboxamide
por: Shishkina, Svitlana V., et al.
Publicado: (2021)

2-Benzyloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one. Corrigendum
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Ethoxy-5-methylbis[1,2,4]triazolo[1,5-a:4′,3′-c]quinazoline
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

Al-Salahi, R. Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines. Molecules 2010, 15, 7016–7034
por: Al-Salahi, Rashad A., et al.
Publicado: (2010)

Diradical reaction mechanisms in [3 + 2]-cycloadditions of hetaryl thioketones with alkyl- or trimethylsilyl-substituted diazomethanes
por: Mlostoń, Grzegorz, et al.
Publicado: (2016)

High urinary interleukin-2 in late post-transplant period portends a risk of decline in kidney allograft function: a preliminary study
por: Trailin, Andriy V., et al.
Publicado: (2017)

Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure
por: Al-Salahi, Rashad, et al.
Publicado: (2014)

Piloting work of outreach nurses in Harm Reduction projects in Ukraine
por: Dvinskykh, Natalya, et al.
Publicado: (2012)

Peritransplant Soluble CD30 as a Risk Factor for Slow Kidney Allograft Function, Early Acute Rejection, Worse Long-Term Allograft Function, and Patients' Survival
por: Trailin, Andriy V., et al.
Publicado: (2017)

5,6,7,8-Tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-9(4H)-one
por: Ettahiri, Walid, et al.
Publicado: (2023)

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity
por: Korotina, Anna V, et al.
Publicado: (2022)

A novel application of 2-silylated 1,3-dithiolanes for the synthesis of aryl/hetaryl-substituted ethenes and dibenzofulvenes
por: Mlostoń, Grzegorz, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_b4m1beb5vmqg7qk8mmb0vlon45