Cargando…

Synthesis, Anti-Inflammatory, and Ulcerogenicity Studies of Novel Substituted and Fused Pyrazolo[3,4-d]pyrimidin-4-ones

In the present investigation, some new pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives (7–12) as well as fused pyrazolo[3′,4′:4,5]pyrimido[1,2-b]pyridazin-4(1H)-one (14–16) and 7,8,9,10-tetrahydropyrazolo[3′,4′:4,5]pyrimido[1,2-b]-cinnolin-4(1H)-one (17) ring systems were synthesized using the starti...

Descripción completa

Detalles Bibliográficos
Autor principal:	El-Tombary, Alaa A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Österreichische Apotheker-Verlagsgesellschaft 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700072/ https://www.ncbi.nlm.nih.gov/pubmed/23833710 http://dx.doi.org/10.3797/scipharm.1211-21

Ejemplares similares

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008)

Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Synthesis and Anticancer Activity of Some New Pyrazolo[3,4-d]pyrimidin-4-one Derivatives
por: Abdellatif, Khaled R. A., et al.
Publicado: (2014)

4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2013)

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
por: Kandeel, Manal M., et al.
Publicado: (2012)

One-Flask Synthesis of Pyrazolo[3,4-d]pyrimidines from 5-Aminopyrazoles and Mechanistic Study
por: Yen, Wan-Ping, et al.
Publicado: (2017)

4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine
por: Dolzhenko, Anton V., et al.
Publicado: (2009)

Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-d]pyrimidin-4-ones
por: Ng, Jia Hui, et al.
Publicado: (2022)

A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
por: Liu, Mingxing, et al.
Publicado: (2015)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
por: Greco, Chiara, et al.
Publicado: (2020)

Synthesis of some novel pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives as potential antimicrobial agent
por: Sureja, Dipen K., et al.
Publicado: (2016)

Crystal structure of 4-allylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

5-(Pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
por: Alsubari, Abdulsalam, et al.
Publicado: (2011)

Pyrazolo-fused 4-azafluorenones as key reagents for the synthesis of fluorescent dicyanovinylidene-substituted derivatives
por: Orrego-Hernández, Jessica, et al.
Publicado: (2019)

Crystal structure of 1-ethylpyrazolo[3,4-d]pyrimidine-4(5H)-thione
por: El Fal, Mohammed, et al.
Publicado: (2014)

One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines
por: Prajapati, Dipak, et al.
Publicado: (2006)

Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives
por: Gomha, Sobhi Mohamed, et al.
Publicado: (2011)

Crystal structure of 1-methyl-4-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

Androgen Receptor Antagonists and Anti-Prostate Cancer Activities of Some Newly Synthesized Substituted Fused Pyrazolo-, Triazolo- and Thiazolo-Pyrimidine Derivatives
por: Bahashwan, Saleh A., et al.
Publicado: (2014)

A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects
por: Lee, Ji Ae, et al.
Publicado: (2022)

1-(2-Chloroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
por: Khazi, Mohammed Iqbal A., et al.
Publicado: (2012)

Anticancer and Anti-Inflammatory Activities of Some New Pyrazolo[3,4-b]pyrazines
por: El-Kashef, Hussein, et al.
Publicado: (2018)

Autophagy Inhibition Enhances Anti-Glioblastoma Effects of Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors
por: Jovanović Stojanov, Sofija, et al.
Publicado: (2022)

Design, synthesis, and biological evaluation with molecular dynamics study of novel pyrazolo[3,4-d]pyrimidine derivatives as anti-cancer agents
por: Shaban, Rania M., et al.
Publicado: (2023)

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
por: Mandour, Asmaa A., et al.
Publicado: (2022)

Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines
por: Atta, Kamal F.M.
Publicado: (2011)

The crystal structure of 1,5-dibenzyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-thione
por: El Fal, Mohammed, et al.
Publicado: (2015)

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery
por: Vignaroli, Giulia, et al.
Publicado: (2016)

Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold
por: Baillache, Daniel J., et al.
Publicado: (2020)

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction
por: Lin, Wei, et al.
Publicado: (2019)

The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl(4)-Induced Liver Fibrosis in Rats
por: Ghobrial, Diana K., et al.
Publicado: (2023)

Synthesis and vectorial functionalisation of pyrazolo[3,4-c]pyridines
por: Bedwell, Elizabeth V., et al.
Publicado: (2023)

Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines
por: Othman, Eman M., et al.
Publicado: (2021)

Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position
por: Al-Afaleq, Eljazi I., et al.
Publicado: (2001)

Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a]pyrimidines
por: Zaki, Yasser Hassan, et al.
Publicado: (2016)

The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
por: Rango, Enrico, et al.
Publicado: (2022)

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors
por: Salem, Ibrahim M., et al.
Publicado: (2022)

Design, Synthesis, Anti-Tubercular Evaluation and Teratogenicity Studies of Furanyl Pyrazolo[3,4-b] Quinoline-5-Ones
por: Babu, N. R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q5i8e3ettb9sp7jjlfs3k6lds1