Nine-year follow-up of local implantation of autologous skeletal myoblasts in a patient with coronary heart disease

PATIENT: gender – Male, age – 63 year-old PRIMARY DIAGNOSIS: Acute myocardial infarction CO-EXISTING DISEASES: Hypertension MEDICATION: Aspirin • beta-blocker • captopril CLINICAL PROCEDURE: CABG • autologous skeletal myoblast transplantation • PCI SPECIALTY: Cardiology OBJECTIVE: Unusual or unexpected effect of treatment. BACKGROUND: Cell transplantation has been viewed as a promising strategy for end-stage heart failure, but long-term follow-up results are lacking. CASE REPORT: In December 2002 we began transplanting autologous skeletal myoblasts in one patient because of serious coronary heart disease. Here, we present the 9-year follow-up results of this patient. No ventricular tachyarrhythmias were detected after treatment. The patient had another myocardial infarction in April 2012 and was treated successful with PCI. CONCLUSIONS: Autologous skeletal myoblast transplantation with bypass surgery is associated with improvement in cardiac function and lack of adverse effects in long-term follow-up, making it a promising therapy for patients with heart failure.