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Feasibility study for a biomedical experimental facility based on LEIR at CERN

In light of the recent European developments in ion beam therapy, there is a strong interest from the biomedical research community to have more access to clinically relevant beams. Beamtime for pre-clinical studies is currently very limited and a new dedicated facility would allow extensive researc...

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Autores principales: Abler, Daniel, Garonna, Adriano, Carli, Christian, Dosanjh, Manjit, Peach, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700518/
https://www.ncbi.nlm.nih.gov/pubmed/23824122
http://dx.doi.org/10.1093/jrr/rrt056
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author Abler, Daniel
Garonna, Adriano
Carli, Christian
Dosanjh, Manjit
Peach, Ken
author_facet Abler, Daniel
Garonna, Adriano
Carli, Christian
Dosanjh, Manjit
Peach, Ken
author_sort Abler, Daniel
collection PubMed
description In light of the recent European developments in ion beam therapy, there is a strong interest from the biomedical research community to have more access to clinically relevant beams. Beamtime for pre-clinical studies is currently very limited and a new dedicated facility would allow extensive research into the radiobiological mechanisms of ion beam radiation and the development of more refined techniques of dosimetry and imaging. This basic research would support the current clinical efforts of the new treatment centres in Europe (for example HIT, CNAO and MedAustron). This paper presents first investigations on the feasibility of an experimental biomedical facility based on the CERN Low Energy Ion Ring LEIR accelerator. Such a new facility could provide beams of light ions (from protons to neon ions) in a collaborative and cost-effective way, since it would rely partly on CERN's competences and infrastructure. The main technical challenges linked to the implementation of a slow extraction scheme for LEIR and to the design of the experimental beamlines are described and first solutions presented. These include introducing new extraction septa into one of the straight sections of the synchrotron, changing the power supply configuration of the magnets, and designing a new horizontal beamline suitable for clinical beam energies, and a low-energy vertical beamline for particular radiobiological experiments.
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spelling pubmed-37005182013-07-05 Feasibility study for a biomedical experimental facility based on LEIR at CERN Abler, Daniel Garonna, Adriano Carli, Christian Dosanjh, Manjit Peach, Ken J Radiat Res Accelerators In light of the recent European developments in ion beam therapy, there is a strong interest from the biomedical research community to have more access to clinically relevant beams. Beamtime for pre-clinical studies is currently very limited and a new dedicated facility would allow extensive research into the radiobiological mechanisms of ion beam radiation and the development of more refined techniques of dosimetry and imaging. This basic research would support the current clinical efforts of the new treatment centres in Europe (for example HIT, CNAO and MedAustron). This paper presents first investigations on the feasibility of an experimental biomedical facility based on the CERN Low Energy Ion Ring LEIR accelerator. Such a new facility could provide beams of light ions (from protons to neon ions) in a collaborative and cost-effective way, since it would rely partly on CERN's competences and infrastructure. The main technical challenges linked to the implementation of a slow extraction scheme for LEIR and to the design of the experimental beamlines are described and first solutions presented. These include introducing new extraction septa into one of the straight sections of the synchrotron, changing the power supply configuration of the magnets, and designing a new horizontal beamline suitable for clinical beam energies, and a low-energy vertical beamline for particular radiobiological experiments. Oxford University Press 2013-07 /pmc/articles/PMC3700518/ /pubmed/23824122 http://dx.doi.org/10.1093/jrr/rrt056 Text en © The Author 2013. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Accelerators
Abler, Daniel
Garonna, Adriano
Carli, Christian
Dosanjh, Manjit
Peach, Ken
Feasibility study for a biomedical experimental facility based on LEIR at CERN
title Feasibility study for a biomedical experimental facility based on LEIR at CERN
title_full Feasibility study for a biomedical experimental facility based on LEIR at CERN
title_fullStr Feasibility study for a biomedical experimental facility based on LEIR at CERN
title_full_unstemmed Feasibility study for a biomedical experimental facility based on LEIR at CERN
title_short Feasibility study for a biomedical experimental facility based on LEIR at CERN
title_sort feasibility study for a biomedical experimental facility based on leir at cern
topic Accelerators
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700518/
https://www.ncbi.nlm.nih.gov/pubmed/23824122
http://dx.doi.org/10.1093/jrr/rrt056
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