Functional analysis of the stem loop S3 and S4 structures in the coronavirus 3′UTR

We designed a series of mutations to separately destabilize two helical stems (designated S3 and S4) predicted by a covariation-based model of the coronavirus 3′UTR (Zust et al., 2008). Mouse hepatitis virus genomes containing three or four nucleotide mutations that destabilize either S3 or S4 were...

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Detalles Bibliográficos
Autores principales: Liu, Pinghua, Yang, Dong, Carter, Kristen, Masud, Faryal, Leibowitz, Julian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700632/
https://www.ncbi.nlm.nih.gov/pubmed/23683838
http://dx.doi.org/10.1016/j.virol.2013.04.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700632/
https://www.ncbi.nlm.nih.gov/pubmed/23683838
http://dx.doi.org/10.1016/j.virol.2013.04.021

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