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Functional analysis of the stem loop S3 and S4 structures in the coronavirus 3′UTR
We designed a series of mutations to separately destabilize two helical stems (designated S3 and S4) predicted by a covariation-based model of the coronavirus 3′UTR (Zust et al., 2008). Mouse hepatitis virus genomes containing three or four nucleotide mutations that destabilize either S3 or S4 were...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700632/ https://www.ncbi.nlm.nih.gov/pubmed/23683838 http://dx.doi.org/10.1016/j.virol.2013.04.021 |