The cilium in lights: new views of an ancient organelle

Nearly all cells have cilia, microtubule based projections from the apical cell surface, and nearly all cells use them in essential and unique ways. How mammalian cilia function in vivo as mechanosensors, signal transducers, or in fluid propulsion has been difficult to study due to lack of tools for...

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Detalles Bibliográficos
Autor principal: Drummond, Iain A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700750/
https://www.ncbi.nlm.nih.gov/pubmed/23822867
http://dx.doi.org/10.1186/1741-7007-11-74
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author Drummond, Iain A
author_facet Drummond, Iain A
author_sort Drummond, Iain A
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description Nearly all cells have cilia, microtubule based projections from the apical cell surface, and nearly all cells use them in essential and unique ways. How mammalian cilia function in vivo as mechanosensors, signal transducers, or in fluid propulsion has been difficult to study due to lack of tools for live imaging of cilia. A new transgenic mouse that enables tissue-specific GFP labeling of cilia creates new opportunities for using live imaging to understand cilium function and to better characterize the many genetic models of ciliopathies. See research article: http://www.ciliajournal.com/content/2/1/8
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spelling pubmed-37007502013-07-04 The cilium in lights: new views of an ancient organelle Drummond, Iain A BMC Biol Commentary Nearly all cells have cilia, microtubule based projections from the apical cell surface, and nearly all cells use them in essential and unique ways. How mammalian cilia function in vivo as mechanosensors, signal transducers, or in fluid propulsion has been difficult to study due to lack of tools for live imaging of cilia. A new transgenic mouse that enables tissue-specific GFP labeling of cilia creates new opportunities for using live imaging to understand cilium function and to better characterize the many genetic models of ciliopathies. See research article: http://www.ciliajournal.com/content/2/1/8 BioMed Central 2013-07-03 /pmc/articles/PMC3700750/ /pubmed/23822867 http://dx.doi.org/10.1186/1741-7007-11-74 Text en Copyright © 2013 Drummond; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Drummond, Iain A
The cilium in lights: new views of an ancient organelle
title The cilium in lights: new views of an ancient organelle
title_full The cilium in lights: new views of an ancient organelle
title_fullStr The cilium in lights: new views of an ancient organelle
title_full_unstemmed The cilium in lights: new views of an ancient organelle
title_short The cilium in lights: new views of an ancient organelle
title_sort cilium in lights: new views of an ancient organelle
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700750/
https://www.ncbi.nlm.nih.gov/pubmed/23822867
http://dx.doi.org/10.1186/1741-7007-11-74
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