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Plasma exchange in severe leptospirosis with multi-organ failure: a case report
INTRODUCTION: Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION: A 67-year-old Caucasian man developed sever...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700770/ https://www.ncbi.nlm.nih.gov/pubmed/23809518 http://dx.doi.org/10.1186/1752-1947-7-169 |
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author | Taylor, Dominic Karamadoukis, Lazarus |
author_facet | Taylor, Dominic Karamadoukis, Lazarus |
author_sort | Taylor, Dominic |
collection | PubMed |
description | INTRODUCTION: Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION: A 67-year-old Caucasian man developed severe leptospirosis with marked icterus, acute kidney injury and cardiorespiratory failure, after exposure to livestock. On the basis of previous reported cases, he was treated with plasma exchange. This led to a rapid improvement in his bilirubin level, cardiac and respiratory function, followed by renal function. CONCLUSION: We discuss the pathophysiology of the disease, and suggest that plasma exchange has a role in the treatment of severe sepsis caused by leptospirosis as well as immune complex-mediated organ injury. |
format | Online Article Text |
id | pubmed-3700770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37007702013-07-04 Plasma exchange in severe leptospirosis with multi-organ failure: a case report Taylor, Dominic Karamadoukis, Lazarus J Med Case Rep Case Report INTRODUCTION: Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION: A 67-year-old Caucasian man developed severe leptospirosis with marked icterus, acute kidney injury and cardiorespiratory failure, after exposure to livestock. On the basis of previous reported cases, he was treated with plasma exchange. This led to a rapid improvement in his bilirubin level, cardiac and respiratory function, followed by renal function. CONCLUSION: We discuss the pathophysiology of the disease, and suggest that plasma exchange has a role in the treatment of severe sepsis caused by leptospirosis as well as immune complex-mediated organ injury. BioMed Central 2013-06-28 /pmc/articles/PMC3700770/ /pubmed/23809518 http://dx.doi.org/10.1186/1752-1947-7-169 Text en Copyright © 2013 Taylor and Karamadoukis; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Taylor, Dominic Karamadoukis, Lazarus Plasma exchange in severe leptospirosis with multi-organ failure: a case report |
title | Plasma exchange in severe leptospirosis with multi-organ failure: a case report |
title_full | Plasma exchange in severe leptospirosis with multi-organ failure: a case report |
title_fullStr | Plasma exchange in severe leptospirosis with multi-organ failure: a case report |
title_full_unstemmed | Plasma exchange in severe leptospirosis with multi-organ failure: a case report |
title_short | Plasma exchange in severe leptospirosis with multi-organ failure: a case report |
title_sort | plasma exchange in severe leptospirosis with multi-organ failure: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700770/ https://www.ncbi.nlm.nih.gov/pubmed/23809518 http://dx.doi.org/10.1186/1752-1947-7-169 |
work_keys_str_mv | AT taylordominic plasmaexchangeinsevereleptospirosiswithmultiorganfailureacasereport AT karamadoukislazarus plasmaexchangeinsevereleptospirosiswithmultiorganfailureacasereport |