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Plasma exchange in severe leptospirosis with multi-organ failure: a case report

INTRODUCTION: Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION: A 67-year-old Caucasian man developed sever...

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Autores principales: Taylor, Dominic, Karamadoukis, Lazarus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700770/
https://www.ncbi.nlm.nih.gov/pubmed/23809518
http://dx.doi.org/10.1186/1752-1947-7-169
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author Taylor, Dominic
Karamadoukis, Lazarus
author_facet Taylor, Dominic
Karamadoukis, Lazarus
author_sort Taylor, Dominic
collection PubMed
description INTRODUCTION: Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION: A 67-year-old Caucasian man developed severe leptospirosis with marked icterus, acute kidney injury and cardiorespiratory failure, after exposure to livestock. On the basis of previous reported cases, he was treated with plasma exchange. This led to a rapid improvement in his bilirubin level, cardiac and respiratory function, followed by renal function. CONCLUSION: We discuss the pathophysiology of the disease, and suggest that plasma exchange has a role in the treatment of severe sepsis caused by leptospirosis as well as immune complex-mediated organ injury.
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spelling pubmed-37007702013-07-04 Plasma exchange in severe leptospirosis with multi-organ failure: a case report Taylor, Dominic Karamadoukis, Lazarus J Med Case Rep Case Report INTRODUCTION: Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION: A 67-year-old Caucasian man developed severe leptospirosis with marked icterus, acute kidney injury and cardiorespiratory failure, after exposure to livestock. On the basis of previous reported cases, he was treated with plasma exchange. This led to a rapid improvement in his bilirubin level, cardiac and respiratory function, followed by renal function. CONCLUSION: We discuss the pathophysiology of the disease, and suggest that plasma exchange has a role in the treatment of severe sepsis caused by leptospirosis as well as immune complex-mediated organ injury. BioMed Central 2013-06-28 /pmc/articles/PMC3700770/ /pubmed/23809518 http://dx.doi.org/10.1186/1752-1947-7-169 Text en Copyright © 2013 Taylor and Karamadoukis; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Taylor, Dominic
Karamadoukis, Lazarus
Plasma exchange in severe leptospirosis with multi-organ failure: a case report
title Plasma exchange in severe leptospirosis with multi-organ failure: a case report
title_full Plasma exchange in severe leptospirosis with multi-organ failure: a case report
title_fullStr Plasma exchange in severe leptospirosis with multi-organ failure: a case report
title_full_unstemmed Plasma exchange in severe leptospirosis with multi-organ failure: a case report
title_short Plasma exchange in severe leptospirosis with multi-organ failure: a case report
title_sort plasma exchange in severe leptospirosis with multi-organ failure: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700770/
https://www.ncbi.nlm.nih.gov/pubmed/23809518
http://dx.doi.org/10.1186/1752-1947-7-169
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