Cargando…
Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene was originally identified as a transformation suppressor gene that is widely expressed in normal tissues. In tumor tissues, RECK expression levels are significantly reduced, and the downregulation of RECK has been implicated...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700891/ https://www.ncbi.nlm.nih.gov/pubmed/23833658 http://dx.doi.org/10.3892/ol.2013.1306 |
_version_ | 1782275554061320192 |
---|---|
author | MAO, XIA LIU, LONGLONG ZHANG, BING ZHANG, DONGHUA |
author_facet | MAO, XIA LIU, LONGLONG ZHANG, BING ZHANG, DONGHUA |
author_sort | MAO, XIA |
collection | PubMed |
description | The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene was originally identified as a transformation suppressor gene that is widely expressed in normal tissues. In tumor tissues, RECK expression levels are significantly reduced, and the downregulation of RECK has been implicated in tumors that are more aggressive with a poor prognosis. In the present study, RECK expression in peripheral T-cell lymphoma (PTCL; n=82) was examined using immunohistochemistry, and its correlation with clinicopathological factors was analyzed. According to the proportion of positively-stained cells and the staining intensity (SI), the patients were categorized into RECK-negative or RECK-positive groups. RECK expression was observed in 30 of the 82 patients (36.6%). The 3-year survival rate of the patients with RECK-positive tumors (65.5%) was significantly high compared with that of the patients with RECK-negative tumors (20.3%; P=0.046). Reduced RECK expression was found to be significantly correlated with extranodal lymphomatous involvement (P=0.012). The survival analysis showed that RECK-negative expression was an independent and significant factor for predicting a poor prognosis. RECK status is a useful prognostic factor for assessing the biological behavior in PTCL. |
format | Online Article Text |
id | pubmed-3700891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37008912013-07-05 Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma MAO, XIA LIU, LONGLONG ZHANG, BING ZHANG, DONGHUA Oncol Lett Articles The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene was originally identified as a transformation suppressor gene that is widely expressed in normal tissues. In tumor tissues, RECK expression levels are significantly reduced, and the downregulation of RECK has been implicated in tumors that are more aggressive with a poor prognosis. In the present study, RECK expression in peripheral T-cell lymphoma (PTCL; n=82) was examined using immunohistochemistry, and its correlation with clinicopathological factors was analyzed. According to the proportion of positively-stained cells and the staining intensity (SI), the patients were categorized into RECK-negative or RECK-positive groups. RECK expression was observed in 30 of the 82 patients (36.6%). The 3-year survival rate of the patients with RECK-positive tumors (65.5%) was significantly high compared with that of the patients with RECK-negative tumors (20.3%; P=0.046). Reduced RECK expression was found to be significantly correlated with extranodal lymphomatous involvement (P=0.012). The survival analysis showed that RECK-negative expression was an independent and significant factor for predicting a poor prognosis. RECK status is a useful prognostic factor for assessing the biological behavior in PTCL. D.A. Spandidos 2013-06 2013-04-16 /pmc/articles/PMC3700891/ /pubmed/23833658 http://dx.doi.org/10.3892/ol.2013.1306 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles MAO, XIA LIU, LONGLONG ZHANG, BING ZHANG, DONGHUA Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma |
title | Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma |
title_full | Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma |
title_fullStr | Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma |
title_full_unstemmed | Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma |
title_short | Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma |
title_sort | reversion-inducing cysteine-rich protein with kazal motifs gene expression and its clinical significance in peripheral t-cell lymphoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700891/ https://www.ncbi.nlm.nih.gov/pubmed/23833658 http://dx.doi.org/10.3892/ol.2013.1306 |
work_keys_str_mv | AT maoxia reversioninducingcysteinerichproteinwithkazalmotifsgeneexpressionanditsclinicalsignificanceinperipheraltcelllymphoma AT liulonglong reversioninducingcysteinerichproteinwithkazalmotifsgeneexpressionanditsclinicalsignificanceinperipheraltcelllymphoma AT zhangbing reversioninducingcysteinerichproteinwithkazalmotifsgeneexpressionanditsclinicalsignificanceinperipheraltcelllymphoma AT zhangdonghua reversioninducingcysteinerichproteinwithkazalmotifsgeneexpressionanditsclinicalsignificanceinperipheraltcelllymphoma |