Structural Studies of a Bacterial tRNA(HIS) Guanylyltransferase (Thg1)-Like Protein, with Nucleotide in the Activation and Nucleotidyl Transfer Sites

All nucleotide polymerases and transferases catalyze nucleotide addition in a 5′ to 3′ direction. In contrast, tRNA(His) guanylyltransferase (Thg1) enzymes catalyze the unusual reverse addition (3′ to 5′) of nucleotides to polynucleotide substrates. In eukaryotes, Thg1 enzymes use the 3′–5′ addition...

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Detalles Bibliográficos
Autores principales: Hyde, Samantha J., Rao, Bhalchandra S., Eckenroth, Brian E., Jackman, Jane E., Doublié, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701042/
https://www.ncbi.nlm.nih.gov/pubmed/23844012
http://dx.doi.org/10.1371/journal.pone.0067465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701042/
https://www.ncbi.nlm.nih.gov/pubmed/23844012
http://dx.doi.org/10.1371/journal.pone.0067465

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