Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions

Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma, colorectal carcinoma, ovarian cancer, papillary t...

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Detalles Bibliográficos
Autores principales: King, Alastair J., Arnone, Marc R., Bleam, Maureen R., Moss, Katherine G., Yang, Jingsong, Fedorowicz, Kelly E., Smitheman, Kimberly N., Erhardt, Joseph A., Hughes-Earle, Angela, Kane-Carson, Laurie S., Sinnamon, Robert H., Qi, Hongwei, Rheault, Tara R., Uehling, David E., Laquerre, Sylvie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701070/
https://www.ncbi.nlm.nih.gov/pubmed/23844038
http://dx.doi.org/10.1371/journal.pone.0067583

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