Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Genetic association studies of age-related, chronic human diseases often suffer from a lack of power to detect modest effects. Here we propose an alternative approach of including healthy centenarians as a more homogeneous and extreme control group. As a proof of principle we focused on type 2 diabe...

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Detalles Bibliográficos
Autores principales: Garagnani, Paolo, Giuliani, Cristina, Pirazzini, Chiara, Olivieri, Fabiola, Bacalini, Maria Giulia, Ostan, Rita, Mari, Daniela, Passarino, Giuseppe, Monti, Daniela, Bonfigli, Anna Rita, Boemi, Massimo, Ceriello, Antonio, Genovese, Stefano, Sevini, Federica, Luiselli, Donata, Tieri, Paolo, Capri, Miriam, Salvioli, Stefano, Vijg, Jan, Suh, Yousin, Delledonne, Massimo, Testa, Roberto, Franceschi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701112/
https://www.ncbi.nlm.nih.gov/pubmed/23804578

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