PML, SUMOylation, and Senescence

Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here w...

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Detalles Bibliográficos
Autores principales: Ivanschitz, Lisa, De Thé, Hugues, Le Bras, Morgane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701148/
https://www.ncbi.nlm.nih.gov/pubmed/23847762
http://dx.doi.org/10.3389/fonc.2013.00171
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author Ivanschitz, Lisa
De Thé, Hugues
Le Bras, Morgane
author_facet Ivanschitz, Lisa
De Thé, Hugues
Le Bras, Morgane
author_sort Ivanschitz, Lisa
collection PubMed
description Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the context of cellular transformation.
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spelling pubmed-37011482013-07-11 PML, SUMOylation, and Senescence Ivanschitz, Lisa De Thé, Hugues Le Bras, Morgane Front Oncol Oncology Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the context of cellular transformation. Frontiers Media S.A. 2013-07-04 /pmc/articles/PMC3701148/ /pubmed/23847762 http://dx.doi.org/10.3389/fonc.2013.00171 Text en Copyright © 2013 Ivanschitz, de Thé and Le Bras. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Ivanschitz, Lisa
De Thé, Hugues
Le Bras, Morgane
PML, SUMOylation, and Senescence
title PML, SUMOylation, and Senescence
title_full PML, SUMOylation, and Senescence
title_fullStr PML, SUMOylation, and Senescence
title_full_unstemmed PML, SUMOylation, and Senescence
title_short PML, SUMOylation, and Senescence
title_sort pml, sumoylation, and senescence
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701148/
https://www.ncbi.nlm.nih.gov/pubmed/23847762
http://dx.doi.org/10.3389/fonc.2013.00171
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