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Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC1 or TSC2 have increased mTORC1 signaling and give rise to...

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Detalles Bibliográficos
Autores principales:	Kim, Seok-Hyung, Kowalski, Marie L., Carson, Robert P., Bridges, L. Richard, Ess, Kevin C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701212/ https://www.ncbi.nlm.nih.gov/pubmed/23580196 http://dx.doi.org/10.1242/dmm.011494

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