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Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage

Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstri...

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Autores principales: Mandel, Yossi, Manivanh, Richard, Dalal, Roopa, Huie, Phil, Wang, Jenny, Brinton, Mark, Palanker, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701318/
https://www.ncbi.nlm.nih.gov/pubmed/23828130
http://dx.doi.org/10.1038/srep02111
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author Mandel, Yossi
Manivanh, Richard
Dalal, Roopa
Huie, Phil
Wang, Jenny
Brinton, Mark
Palanker, Daniel
author_facet Mandel, Yossi
Manivanh, Richard
Dalal, Roopa
Huie, Phil
Wang, Jenny
Brinton, Mark
Palanker, Daniel
author_sort Mandel, Yossi
collection PubMed
description Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels dilated back to their original size within minutes after stimulation. At higher settings, a blood clotting formed, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery during the first minute after injury was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.
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spelling pubmed-37013182013-07-08 Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage Mandel, Yossi Manivanh, Richard Dalal, Roopa Huie, Phil Wang, Jenny Brinton, Mark Palanker, Daniel Sci Rep Article Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels dilated back to their original size within minutes after stimulation. At higher settings, a blood clotting formed, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery during the first minute after injury was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients. Nature Publishing Group 2013-07-04 /pmc/articles/PMC3701318/ /pubmed/23828130 http://dx.doi.org/10.1038/srep02111 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Mandel, Yossi
Manivanh, Richard
Dalal, Roopa
Huie, Phil
Wang, Jenny
Brinton, Mark
Palanker, Daniel
Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
title Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
title_full Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
title_fullStr Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
title_full_unstemmed Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
title_short Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
title_sort vasoconstriction by electrical stimulation: new approach to control of non-compressible hemorrhage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701318/
https://www.ncbi.nlm.nih.gov/pubmed/23828130
http://dx.doi.org/10.1038/srep02111
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