Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

Malonyl-coenzyme A decarboxylase (MCD) is found from bacteria to humans, has important roles in regulating fatty acid metabolism and food intake, and is an attractive target for drug discovery. We report here four crystal structures of MCD from human, Rhodopseudomonas palustris, Agrobacterium vitis,...

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Detalles Bibliográficos
Autores principales: Froese, D. Sean, Forouhar, Farhad, Tran, Timothy H., Vollmar, Melanie, Kim, Yi Seul, Lew, Scott, Neely, Helen, Seetharaman, Jayaraman, Shen, Yang, Xiao, Rong, Acton, Thomas B., Everett, John K., Cannone, Giuseppe, Puranik, Sriharsha, Savitsky, Pavel, Krojer, Tobias, Pilka, Ewa S., Kiyani, Wasim, Lee, Wen Hwa, Marsden, Brian D., von Delft, Frank, Allerston, Charles K., Spagnolo, Laura, Gileadi, Opher, Montelione, Gaetano T., Oppermann, Udo, Yue, Wyatt W., Tong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701320/
https://www.ncbi.nlm.nih.gov/pubmed/23791943
http://dx.doi.org/10.1016/j.str.2013.05.001

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