FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradoxically restricted to acute myeloid leukemia even t...

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Detalles Bibliográficos
Autores principales: Mead, Adam J., Kharazi, Shabnam, Atkinson, Deborah, Macaulay, Iain, Pecquet, Christian, Loughran, Stephen, Lutteropp, Michael, Woll, Petter, Chowdhury, Onima, Luc, Sidinh, Buza-Vidas, Natalija, Ferry, Helen, Clark, Sally-Ann, Goardon, Nicolas, Vyas, Paresh, Constantinescu, Stefan N., Sitnicka, Ewa, Nerlov, Claus, Jacobsen, Sten Eirik W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701326/
https://www.ncbi.nlm.nih.gov/pubmed/23727242
http://dx.doi.org/10.1016/j.celrep.2013.04.031

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