Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests

The inclusion of volatile derivatives of benzene and cyclohexane in β-cyclodextrin (β-CD), hydroxypropyl-β-CD, and hydrophilic β-CD-thioethers was investigated by static headspace gas chromatography (HS-GC) and molecular modelling. The obtained binding constants strongly increase with the amount of...

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Detalles Bibliográficos
Autores principales: Fourmentin, Sophie, Ciobanu, Anca, Landy, David, Wenz, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701372/
https://www.ncbi.nlm.nih.gov/pubmed/23843912
http://dx.doi.org/10.3762/bjoc.9.133
Descripción
Sumario:The inclusion of volatile derivatives of benzene and cyclohexane in β-cyclodextrin (β-CD), hydroxypropyl-β-CD, and hydrophilic β-CD-thioethers was investigated by static headspace gas chromatography (HS-GC) and molecular modelling. The obtained binding constants strongly increase with the amount of space filling of the CD cavity and the salt concentration. β-CD thioethers show a 3–10 times higher binding potential than native β-CD.

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