Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation

An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products t...

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Autores principales: Trzoss, Lynnie, Xu, Jing, Lacoske, Michelle H, Theodorakis, Emmanuel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701413/
https://www.ncbi.nlm.nih.gov/pubmed/23843905
http://dx.doi.org/10.3762/bjoc.9.126
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author Trzoss, Lynnie
Xu, Jing
Lacoske, Michelle H
Theodorakis, Emmanuel A
author_facet Trzoss, Lynnie
Xu, Jing
Lacoske, Michelle H
Theodorakis, Emmanuel A
author_sort Trzoss, Lynnie
collection PubMed
description An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products that holds remarkable therapeutic potential for neurodegenerative diseases.
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spelling pubmed-37014132013-07-10 Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation Trzoss, Lynnie Xu, Jing Lacoske, Michelle H Theodorakis, Emmanuel A Beilstein J Org Chem Full Research Paper An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products that holds remarkable therapeutic potential for neurodegenerative diseases. Beilstein-Institut 2013-06-12 /pmc/articles/PMC3701413/ /pubmed/23843905 http://dx.doi.org/10.3762/bjoc.9.126 Text en Copyright © 2013, Trzoss et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Trzoss, Lynnie
Xu, Jing
Lacoske, Michelle H
Theodorakis, Emmanuel A
Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation
title Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation
title_full Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation
title_fullStr Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation
title_full_unstemmed Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation
title_short Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation
title_sort synthesis of the tetracyclic core of illicium sesquiterpenes using an organocatalyzed asymmetric robinson annulation
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701413/
https://www.ncbi.nlm.nih.gov/pubmed/23843905
http://dx.doi.org/10.3762/bjoc.9.126
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