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CD133: a stem cell biomarker and beyond
Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as we...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701589/ https://www.ncbi.nlm.nih.gov/pubmed/23815814 http://dx.doi.org/10.1186/2162-3619-2-17 |
| _version_ | 1782275670986981376 |
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| author | Li, Zhong |
| author_facet | Li, Zhong |
| author_sort | Li, Zhong |
| collection | PubMed |
| description | Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as well as cell lines since its discovery in 1999. Recent studies are focusing on the functionality of CD133. In this review, we summarize new insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration. |
| format | Online Article Text |
| id | pubmed-3701589 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37015892013-07-05 CD133: a stem cell biomarker and beyond Li, Zhong Exp Hematol Oncol Review Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as well as cell lines since its discovery in 1999. Recent studies are focusing on the functionality of CD133. In this review, we summarize new insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration. BioMed Central 2013-07-01 /pmc/articles/PMC3701589/ /pubmed/23815814 http://dx.doi.org/10.1186/2162-3619-2-17 Text en Copyright © 2013 Li; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Li, Zhong CD133: a stem cell biomarker and beyond |
| title | CD133: a stem cell biomarker and beyond |
| title_full | CD133: a stem cell biomarker and beyond |
| title_fullStr | CD133: a stem cell biomarker and beyond |
| title_full_unstemmed | CD133: a stem cell biomarker and beyond |
| title_short | CD133: a stem cell biomarker and beyond |
| title_sort | cd133: a stem cell biomarker and beyond |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701589/ https://www.ncbi.nlm.nih.gov/pubmed/23815814 http://dx.doi.org/10.1186/2162-3619-2-17 |
| work_keys_str_mv | AT lizhong cd133astemcellbiomarkerandbeyond |