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A Huntingtin Peptide Inhibits PolyQ-Huntingtin Associated Defects
BACKGROUND: Huntington’s disease (HD) is caused by the abnormal expansion of the polyglutamine tract in the human Huntingtin protein (polyQ-hHtt). Although this mutation behaves dominantly, huntingtin loss of function also contributes to HD pathogenesis. Indeed, wild-type Huntingtin plays a protecti...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701666/ https://www.ncbi.nlm.nih.gov/pubmed/23861941 http://dx.doi.org/10.1371/journal.pone.0068775 |