Cargando…

Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach

Most chronic viral infections are managed with small molecule therapies that inhibit replication but are not curative because non-replicating viral forms can persist despite decades of suppressive treatment. There are therefore numerous strategies in development to eradicate all non-replicating viru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schiffer, Joshua T., Swan, Dave A., Stone, Daniel, Jerome, Keith R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701691/ https://www.ncbi.nlm.nih.gov/pubmed/23861664 http://dx.doi.org/10.1371/journal.pcbi.1003131

Ejemplares similares

On the DNA cleavage mechanism of Type I restriction enzymes
por: Jindrova, Eva, et al.
Publicado: (2005)

Anti-proliferative therapy for HIV cure: a compound interest approach
por: Reeves, Daniel B., et al.
Publicado: (2017)

Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes
por: Chand, Mahesh Kumar, et al.
Publicado: (2015)

Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa
por: Schiffer, Joshua T., et al.
Publicado: (2016)

Quantum Mechanical/Molecular Mechanical Free Energy Simulations of the Self-Cleavage Reaction in the Hepatitis Delta Virus Ribozyme
por: Ganguly, Abir, et al.
Publicado: (2014)

AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
por: Weber, Nicholas D., et al.
Publicado: (2014)

DNA cleavage and methylation specificity of the single polypeptide restriction–modification enzyme LlaGI
por: Smith, Rachel M., et al.
Publicado: (2009)

Functional Coupling of Duplex Translocation to DNA Cleavage in a Type I Restriction Enzyme
por: Csefalvay, Eva, et al.
Publicado: (2015)

Dicer-like Enzymes with Sequence Cleavage Preferences
por: Hoehener, Cristina, et al.
Publicado: (2018)

Evolving AAV-delivered therapeutics towards ultimate cures
por: He, Xiangjun, et al.
Publicado: (2021)

Targeting Viral cccDNA for Cure of Chronic Hepatitis B
por: Ligat, Gaëtan, et al.
Publicado: (2020)

Recycling of protein subunits during DNA translocation and cleavage by Type I restriction-modification enzymes
por: Simons, Michelle, et al.
Publicado: (2011)

DNA cleavage by Type ISP Restriction–Modification enzymes is initially targeted to the 3′-5′ strand
por: van Aelst, Kara, et al.
Publicado: (2013)

An ounce of prevention is worth a pound of cure: considerations for pharmacists delivering the National Diabetes Prevention Program
por: Dixon, Dave L., et al.
Publicado: (2021)

An investigation of the structural requirements for ATP hydrolysis and DNA cleavage by the EcoKI Type I DNA restriction and modification enzyme
por: Roberts, Gareth A., et al.
Publicado: (2011)

Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA
por: Liu, Mu-Sen, et al.
Publicado: (2020)

Chronic Hepatitis B Infection: New Approaches towards Cure
por: Ogunnaike, Mojisola, et al.
Publicado: (2023)

Cholesterol Side-Chain Cleavage Enzyme (SCC) Deficiency
por: Katsumata, Noriyuki
Publicado: (2007)

Effect of pH on Cleavage of Glycogen by Vaginal Enzymes
por: Spear, Greg T., et al.
Publicado: (2015)

The conserved single-cleavage mechanism of animal DROSHA enzymes
por: Nguyen, Thuy Linh, et al.
Publicado: (2021)

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
por: Ramanan, Vyas, et al.
Publicado: (2015)

Glycosylases and AP-cleaving enzymes as a general tool for probe-directed cleavage of ssDNA targets
por: Howell, W. Mathias, et al.
Publicado: (2010)

DNA synapsis through transient tetramerization triggers cleavage by Ecl18kI restriction enzyme
por: Zaremba, Mindaugas, et al.
Publicado: (2010)

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA–topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts
por: Dexheimer, Thomas S., et al.
Publicado: (2008)

Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation
por: Sasnauskas, Giedrius, et al.
Publicado: (2011)

Clinical Predictors of Functional Cure in Children 1–6 Years-old with Chronic Hepatitis B
por: Pan, Jing, et al.
Publicado: (2022)

8-Oxoguanine Affects DNA Backbone Conformation in the EcoRI Recognition Site and Inhibits Its Cleavage by the Enzyme
por: Hoppins, Joanna J., et al.
Publicado: (2016)

Sequence-specific cleavage of RNA by Type II restriction enzymes
por: Murray, Iain A., et al.
Publicado: (2010)

Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
por: Sowinska, Agnieszka, et al.
Publicado: (2020)

The failure of radical treatments to cure cancer: can less deliver more?
por: Dalgleish, Angus G., et al.
Publicado: (2018)

DNA of a circular minichromosome linearized by restriction enzymes or other reagents is resistant to further cleavage: an influence of chromatin topology on the accessibility of DNA
por: Kumala, Sławomir, et al.
Publicado: (2012)

Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations
por: van Aelst, Kara, et al.
Publicado: (2015)

Hepatic Colic Cured by Chloroform
por: Smith, Q. C.
Publicado: (1875)

DNA sequencing by MALDI-TOF MS using alkali cleavage of RNA/DNA chimeras
por: Mauger, Florence, et al.
Publicado: (2007)

Dr. Euler's fabulous formula: Cures many mathematical ills
por: Nahin, Paul J
Publicado: (2006)

Mathematical Modeling of Vaccines That Prevent SARS-CoV-2 Transmission
por: Swan, David A., et al.
Publicado: (2021)

Single-site DNA cleavage by Type III restriction endonuclease requires a site-bound enzyme and a trans-acting enzyme that are ATPase-activated
por: Ahmad, Ishtiyaq, et al.
Publicado: (2018)

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain
por: Hilbert, Brendan J., et al.
Publicado: (2017)

Study on the Retreatment, Outcome, and Potential Predictors of Recurrence in Patients With Recurrence of Hepatitis B After Functional Cure
por: Lin, Xiao, et al.
Publicado: (2022)

Kernel functions and elliptic differential equations in mathematical physics
por: Bergman, Stefan, et al.
Publicado: (1953)

Cannot write session to /tmp/vufind_sessions/sess_ka1jsl2i67871pbdm3luqtv6u8