Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2A(Cdc55) for Timely Mitotic Progression

Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of the endosulfine family and allows them to bind and inhibit the main Cdk1-counteracting PP2A-B55 phosphatase, thereby promoting mitotic entry...

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Detalles Bibliográficos
Autores principales: Juanes, Maria Angeles, Khoueiry, Rita, Kupka, Thomas, Castro, Anna, Mudrak, Ingrid, Ogris, Egon, Lorca, Thierry, Piatti, Simonetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701715/
https://www.ncbi.nlm.nih.gov/pubmed/23861665
http://dx.doi.org/10.1371/journal.pgen.1003575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701715/
https://www.ncbi.nlm.nih.gov/pubmed/23861665
http://dx.doi.org/10.1371/journal.pgen.1003575

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