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Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its ligands are well characterized in vitro, quantitative measurements of these interactions in living cells are required to...

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Detalles Bibliográficos
Autores principales:	O'Donoghue, Geoff P, Pielak, Rafal M, Smoligovets, Alexander A, Lin, Jenny J, Groves, Jay T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701909/ https://www.ncbi.nlm.nih.gov/pubmed/23840928 http://dx.doi.org/10.7554/eLife.00778

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