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Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition
Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target in cancer and...
Autores principales: | Mohan, Pooja, Castellsague, Joan, Jiang, Jihong, Allen, Kristi, Chen, Helen, Nemirovsky, Oksana, Spyra, Melanie, Hu, Kaiji, Kluwe, Lan, Pujana, Miguel Angel, Villanueva, Alberto, Mautner, Victor F., Keats, Jonathan J., Dunn, Sandra E., Lazaro, Conxi, Maxwell, Christopher A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702209/ https://www.ncbi.nlm.nih.gov/pubmed/23328114 |
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