Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention

Familial melanoma (FM) is a dominantly heritable cancer that is associated with mutations in the tumor suppressor CDKN2A/p16. In FM, a single inherited “hit” occurs in every somatic cell, enabling interrogation of cultured normal skin fibroblasts (SFs) from FM gene carriers as surrogates for the cel...

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Detalles Bibliográficos
Autores principales: Fan, Meiyun, Pfeffer, Susan R., Lynch, Henry T., Cassidy, Pamela, Leachman, Sancy, Pfeffer, Lawrence M., Kopelovich, Levy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702213/
https://www.ncbi.nlm.nih.gov/pubmed/23371019

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