TiPs: a database of therapeutic targets in pathogens and associated tools

Motivation: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we desc...

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Detalles Bibliográficos
Autores principales: Lepore, Rosalba, Tramontano, Anna, Via, Allegra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702258/
https://www.ncbi.nlm.nih.gov/pubmed/23698860
http://dx.doi.org/10.1093/bioinformatics/btt289
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author Lepore, Rosalba
Tramontano, Anna
Via, Allegra
author_facet Lepore, Rosalba
Tramontano, Anna
Via, Allegra
author_sort Lepore, Rosalba
collection PubMed
description Motivation: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug–target pairs for 150 human pathogens derived from available drug–target crystallographic complexes. Availability and implementation: The TiPs database is freely available at http://biocomputing.it/tips. Contact: anna.tramontano@uniroma1.it or allegra.via@uniroma1.it
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spelling pubmed-37022582013-07-05 TiPs: a database of therapeutic targets in pathogens and associated tools Lepore, Rosalba Tramontano, Anna Via, Allegra Bioinformatics Applications Notes Motivation: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug–target pairs for 150 human pathogens derived from available drug–target crystallographic complexes. Availability and implementation: The TiPs database is freely available at http://biocomputing.it/tips. Contact: anna.tramontano@uniroma1.it or allegra.via@uniroma1.it Oxford University Press 2013-07-15 2013-05-21 /pmc/articles/PMC3702258/ /pubmed/23698860 http://dx.doi.org/10.1093/bioinformatics/btt289 Text en © The Author 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Lepore, Rosalba
Tramontano, Anna
Via, Allegra
TiPs: a database of therapeutic targets in pathogens and associated tools
title TiPs: a database of therapeutic targets in pathogens and associated tools
title_full TiPs: a database of therapeutic targets in pathogens and associated tools
title_fullStr TiPs: a database of therapeutic targets in pathogens and associated tools
title_full_unstemmed TiPs: a database of therapeutic targets in pathogens and associated tools
title_short TiPs: a database of therapeutic targets in pathogens and associated tools
title_sort tips: a database of therapeutic targets in pathogens and associated tools
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702258/
https://www.ncbi.nlm.nih.gov/pubmed/23698860
http://dx.doi.org/10.1093/bioinformatics/btt289
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AT tramontanoanna tipsadatabaseoftherapeutictargetsinpathogensandassociatedtools
AT viaallegra tipsadatabaseoftherapeutictargetsinpathogensandassociatedtools

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