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Pathway Processor 2.0: a web resource for pathway-based analysis of high-throughput data

Summary: Pathway Processor 2.0 is a web application designed to analyze high-throughput datasets, including but not limited to microarray and next-generation sequencing, using a pathway centric logic. In addition to well-established methods such as the Fisher’s test and impact analysis, Pathway Proc...

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Detalles Bibliográficos
Autores principales: Beltrame, Luca, Bianco, Luca, Fontana, Paolo, Cavalieri, Duccio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702260/
https://www.ncbi.nlm.nih.gov/pubmed/23740747
http://dx.doi.org/10.1093/bioinformatics/btt292
Descripción
Sumario:Summary: Pathway Processor 2.0 is a web application designed to analyze high-throughput datasets, including but not limited to microarray and next-generation sequencing, using a pathway centric logic. In addition to well-established methods such as the Fisher’s test and impact analysis, Pathway Processor 2.0 offers innovative methods that convert gene expression into pathway expression, leading to the identification of differentially regulated pathways in a dataset of choice. Availability and implementation: Pathway Processor 2.0 is available as a web service at http://compbiotoolbox.fmach.it/pathwayProcessor/. Sample datasets to test the functionality can be used directly from the application. Contact: duccio.cavalieri@fmach.it Supplementary information: Supplementary data are available at Bioinformatics online.