Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy

In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical for their clinical use. However, the relationship between stem-cell expansion and genetic stability is poorly understood. Here, we demonstrat...

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Detalles Bibliográficos
Autores principales: Estrada, J C, Torres, Y, Benguría, A, Dopazo, A, Roche, E, Carrera-Quintanar, L, Pérez, R A, Enríquez, J A, Torres, R, Ramírez, J C, Samper, E, Bernad, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702285/
https://www.ncbi.nlm.nih.gov/pubmed/23807220
http://dx.doi.org/10.1038/cddis.2013.211

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