Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling

Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to produce 1-methylnicotinamide (MeN). We have previously shown that NNMT expression protected against neurotoxin-mediated cell death by increasing Complex I (CxI) activity, resulting in increased ATP synthesis. This was...

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Detalles Bibliográficos
Autores principales: Thomas, M G, Saldanha, M, Mistry, R J, Dexter, D T, Ramsden, D B, Parsons, R B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702289/
https://www.ncbi.nlm.nih.gov/pubmed/23764850
http://dx.doi.org/10.1038/cddis.2013.200

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