Cargando…
A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1
FUS1/TUSC2 is a mitochondrial tumor suppressor with activity to regulate cellular oxidative stress by maintaining balanced ROS production and mitochondrial homeostasis. Fus1 expression is inhibited by ROS, suggesting that individuals with a high level of ROS may have lower Fus1 in normal tissues and...
Autores principales: | Yazlovitskaya, E M, Uzhachenko, R, Voziyan, P A, Yarbrough, W G, Ivanova, A V |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702292/ https://www.ncbi.nlm.nih.gov/pubmed/23788044 http://dx.doi.org/10.1038/cddis.2013.212 |
Ejemplares similares
-
Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice
por: Yazlovitskaya, E M, et al.
Publicado: (2015) -
Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity
por: Uzhachenko, Roman, et al.
Publicado: (2015) -
Mitochondrial Fus1/Tusc2 and cellular Ca2(+) homeostasis: tumor suppressor, anti-inflammatory and anti-aging implications
por: Uzhachenko, Roman, et al.
Publicado: (2022) -
Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis
por: Uzhachenko, Roman, et al.
Publicado: (2017) -
Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS
por: An, Haiyan, et al.
Publicado: (2020)