Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

The histone methyltransferase G9a is overexpressed in a variety of cancer types, including pancreatic adenocarcinoma, and promotes tumor invasiveness and metastasis. We recently reported the discovery of BRD4770, a small-molecule inhibitor of G9a that induces senescence in PANC-1 cells. We observed...

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Detalles Bibliográficos
Autores principales: Yuan, Y, Tang, A J, Castoreno, A B, Kuo, S-Y, Wang, Q, Kuballa, P, Xavier, R, Shamji, A F, Schreiber, S L, Wagner, B K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702302/
https://www.ncbi.nlm.nih.gov/pubmed/23807219
http://dx.doi.org/10.1038/cddis.2013.191

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