Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation

BACKGROUND: Autosomal Emery-Dreifuss muscular dystrophy is caused by mutations in the lamin A/C gene (LMNA) encoding A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. Classically, the disease manifests as scapulo-humeroperoneal muscle wasting and weakness, early joint co...

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Detalles Bibliográficos
Autores principales: Muchir, Antoine, Kim, Young Jin, Reilly, Sarah A, Wu, Wei, Choi, Jason C, Worman, Howard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702458/
https://www.ncbi.nlm.nih.gov/pubmed/23815988
http://dx.doi.org/10.1186/2044-5040-3-17

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